Conference

Thursday, 27 March

14h00 in Amphithéâtre 7- University of Lorraine, Faculty of Sciences, Vandeouvre

As part of the series of conferences organized with support from LabEx ARBRE, Romain Koszul with the Pasteur Institute will present a lecture entitled ‘Ideas on the diverse organization of chromosomes in eukaryotic or prokaryotic microorganisms ‘.

Click here to read the full résumé

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Romain Koszul
Genetics of genomes – CNRS/Institut Pasteur, Paris

Roman Koszul is a biologist and an agricultural engineer by training and a former student of the Université Paris-Sud and AgroParisTech. From 2001 to 2004, he prepared a doctorate in biology at the Université Pierre et Marie Curie and Institut Pasteur. In 2005, he joined Nancy Kleckner’s laboratory at Harvard University where he concentrated his work for four years on the interface between physics and biology and the mechanical properties and dynamics of chromosomes. Recruited by the CNRS in 2008 as a research fellow, he has just put together a team at the Pasteur Institute to work on the “spatial regulation of genomes”.

Dynamic interaction between eukaryotic chromosomes: impact on the stability of the genome (DICIG)

This project aims to understand the functional and mechanical interactions between chromosomes, nuclear periphery and cytoskeleton, as well as their influence on genomic stability, through in vivo and in vitro approaches in a eukaryotic model, the yeast Saccharomyces cerevisiae. Genomic studies, combined with analyses of quantitative microscopy, allow researchers to precisely describe the organization of chromosomes relative to each other, in different genetic backgrounds. Genetic experimentation permits researchers to measure the significance of this organization in processes related to DNA metabolism.