Tuber melanosporum DB

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Gene Name: GSTUMT00007174001
Length(AA) : 406
Localization : scaffold_33
Number of EST contigs matching the gene: 2
Number of ESTs : 7
  User annotation : No user annotation

Blast Results:

Nr Definition: conserved proline-rich protein
Specie: [Aspergillus clavatus NRRL 1]
Accession: ref|XP_001269107.1| Score: 180 E_value: 2e-11
KEGG Definition: hypothetical protein
Accession: ani:AN1120.2 Score: 180 E_value: 1e-11
KOG Definition: WASP-interacting protein VRP1/WIP
Classification: [
Kog Number: KOG4462 Score: 509 E_value: 3e-52
PFAM Definition: Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity..
Pfam Number: pfam03154 Score: 242 E_value: 3e-21
Swissprot: No Hit Found

SignalP

SignalP 3.0 predicts the presence and location of signal peptide cleavage sites in amino acid sequences.
The method incorporates a prediction of cleavage sites and a signal peptide/non-signal peptide prediction
based on a combination of several artificial neural networks and hidden Markov models.

Neural networkHMM
Smean scoreSmean predictionSmax scoreSmax predictionD-scoreD predictionHMM prediction
0.342NO0.397NO0.196NON

TargetP

TargetP 1.1 predicts the subcellular location of eukaryotic proteins. The location assignment is based on
the predicted presence of any of the N-terminal presequences: mitochondrial targeting peptide (mTP)
or secretory pathway signal peptide (SP).

Mitochondrion ScoreSecretory ScoreAny other locationLocalizationReliability classPredicted presenquence length
0.0570.170.855_20

TMHMM

Prediction of transmembrane helices in proteins

ExpAA=0.01607First60=0PredHel=0
Topology=()

ExpAA: The expected number of amino acids intransmembrane helices.
First60: The expected number of amino acids in transmembrane helices in the first 60 amino acids of the protein.
PredHel: The number of predicted transmembrane helices by N-best.
Topology: The topology predicted by N-best.

Sequence:
>GSTUMT00007174001
MPAPPPPPPLPNFGGGPPPPPPPPPPGGGGLIGRPAKGGDRGALNSDITK
GIKLRKAVTNDRSAPAVAGAVGGGGGGGRVASLGAPPVPGAPPIPRARAG
SDGERARSNSDAGGGSGGGGGGLVTAAPQLGGLFAGGMPRLKSRSGGVDT
GASRDSSYISDSESTPPRSAPIPPRMPPMPPRVGLRPTPAAPTGSAPIIP
SQASLRRPPPAPIKRPVSSIPIRGAPGSPSSPPSRATPPPPPPSSLVPSR
PLPLRKTPSPTSHTQTDSPPPSAPPPPPIPGSAPRVLPPGPPRSNPPPPP
LLPVNGSPNPALAAARKVSATLGAHPPAPPPPPPSAARQSQPLPQQRDFM
DSSKFTLTKKKMEINDSRWKFKREEDLPEPRPFTGVRKVYRSGRGSSVPL
DFESLE

EST contigs matching with the Gene:

ContigBest BlastXE-value
Contig1354 hypothetical protein SS1G_06679 [Sclerotinia sclerotiorum 1980]6e-08
Contig6388 No hit found


Manual Annotation:

Please find below the necessary files for GSTUMT00007174001 annotation :

link to GSTUMT00007174001 Artemis file
link to scaffold_33 sequence file
link to scaffold_33ESTs