Tuber melanosporum DB

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Contig Name: SY0AAD5YA15FM1
Length(NT) : 588
Best Gene Model Blast : Link to GSTUMT00005071001 E-value : 0.0
Numbers of ESTs : 1

Blast Results:

Nr Definition: hypothetical protein AN0806.2
Accession: ref|XP_658410.1| Score: 220 E_value: 1e-16
KEGG Definition: hypothetical protein
Accession: ani:AN0806.2 Score: 220 E_value: 7e-17
KOG Definition:
Classification: [General function prediction only].
Kog Number: KOG1188 Score: 232 E_value: 2e-20
PFAM Definition: Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity..
Pfam Number: pfam03154 Score: 122 E_value: 8e-08
Swissprot: Q9Y7T2|YCJ6_SCHPO
Gene Ontology:
GO:0005829 = Cellular component: cytosol
GO:0005634 = Cellular component: nucleus

Sequence:
>SY0AAD5YA15FM1
TTGGATAACCTTCTCCAAATCTACCCTAACGCCAACAAGCACCATCCCAC
ACGCACACACAAACATAACCTCACTTGGCACCTACCCCGCATCACCACAG
ACCCTGCTAACCTCGGGCGCTGACGGGCTCATAAAACTCTGGGACCTCCG
CTGCTCCCCGACAGCCGCTTTGGCGAGCAAGATAAACGTGGGCGCACCAG
TACTATGCGCTTCTGCGAACGCTCAGGGCGGAATCATCGCGGGGACCGAG
GTGCAGGATCGGGCCTCGAGGGTCTGTGTTTGGGATGGGAGAGTGGTGGG
GGAGAAGCCGACCTGGGTGTTCACGGAGAGTCATGGGGATGATGTCTCGT
TTGTGGGGTTTGCCGGGGGAGAAGAGGAGGGGAGGTGGGGAGTTAGTGGG
GGGATGGATGGACTGGTTAATGTTTTTGATTTGCTGGCTGGGAAGGGAGC
GGGAAGGGAGGATGATGATGAGAAGGCACTTTGGCAAGTGGTTAATGTTG
GGGCTTCGGTTCACCGGGCGGGGTTTTTGAATGCTGGTGGCGGTGGTGGT
ATTGTTGGGAAAGGGGAGTGGGTTTTTGGGGTATCGAC

Sequences in the Contig:

SY0AAD5YA15FM1