Tuber melanosporum DB

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Contig Name: SY0AAB54YH16FM1
Length(NT) : 554
Best Gene Model Blast : Link to GSTUMT00009323001 E-value : 0.0
Numbers of ESTs : 1

Blast Results:

Nr Definition: No Hit Found
KEGG Definition: No Hit Found
KOG Definition:
Classification: [Cytoskeleton].
Kog Number: KOG4462 Score: 116 E_value: 4e-07
PFAM Definition: Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity..
Pfam Number: pfam03154 Score: 126 E_value: 3e-08

Sequence:
>SY0AAB54YH16FM1
TTGGCGCTATTGGGGTATTGTTTCGCGCCGCCGGTATACGATACTGCTGC
TGGCGCTGCTAGTGTGGTAATGGGGTTGACAAAGGTGGGCGTGTCCGGGA
ATAGGATATCACGGCGGTCGGCACAGATGTTGCTTAGGACCACCCGATTG
GCCTCGCTGGATGTTGGTCCGTTGGAGTCCGTCGATGGGATCATGGCCAC
AGTCAAGATATACGCTGTGGCGAATCTGGACTACTTGAGGATCGACTGGA
GGGTTGTTCTCGATCCTGCCTTTGTGGGGGTTGGAAGGCTGGTGCTTGTT
AATGTCCCCACATTCGCTAGTCCCCGTGCGGCCCGGGGGATCGCCGCGGT
GGTTGGGGCGGAGGGGGTGAGGGTGCTAGAGCTGGAGATGGAGGTTGGCG
ATGGGTCCGGCGATTTCTCTTTCTTTGACGACGAGGCTGGAGGGAGGGAG
AAAGAGGAGAGGGGGAATGTGGACGTGCTCTCTTCAGTTGCGAAACGCAA
GAGGGAGATTGGATGGCGCGGGAAGGTGAGGGTTGTTAGGGATTTGGCCG
GCGG

Sequences in the Contig:

SY0AAB54YH16FM1