Tuber melanosporum DB

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Contig Name: Contig4471
Length(NT) : 894
Best Gene Model Blast : Link to GSTUMT00012251001 E-value : 0.0
Numbers of ESTs : 2

Blast Results:

Nr Definition: hypothetical protein SS1G_09008
Accession: ref|XP_001590244.1| Score: 152 E_value: 2e-08
KEGG Definition: hypothetical protein
Accession: fgr:FG05213.1 Score: 147 E_value: 4e-08
KOG Definition:
Classification: [Cytoskeleton].
Kog Number: KOG4462 Score: 194 E_value: 8e-16
PFAM Definition: Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity..
Pfam Number: pfam03154 Score: 162 E_value: 4e-12
Swissprot: Q2U968|SEC16_ASPOR
Gene Ontology:
GO:0005789 = Cellular component: endoplasmic reticulum membrane

Sequence:
>Contig4471
TTGGCGGGTGCGGCCCCATACGCTTCACCTGTGAATGCCCCCCCAGCTGG
TGGAGTCAAATATGCACCTCGGCCCGCAGGACCACCCCAGGTCGGAAATC
GAGTTCCATCTGGTGGATTCGTCCCACCTCCACATCAAGCTCCAACCGCA
CAGCAGCCTTTGATGAGCCCGCCACCAATGACCCCCCAAGGCCCCTCGTA
TCAAGATTCATTTACGGCATCTCCGCCCTCACAACATCCCCATTCCCCGG
AGGATCCATCTCATAGCCATCCAAGACGGCTCTCTGGCGAGCATCATGCT
ATGCACTCGTCGCGCCCAGGGACTGCGAGATCTGTGCAGGCTTCGGCAAT
GGATATACCTAGAGAAGAGGAAGAAGAAGGTGCAACTAACCCACCTCAGA
CGCTCCAGAATAATGGATGCCCTTCACAGTTGCCACAACCAGGCGTCCCT
CCGCCTGCGCAAAGCCGGTATGCACCCTCAAGGGATCCCGGGAGAGATTC
GCCCGCTAGTTTACCTTCGGTTACTCGCCAAAATACCTTTACACCTCCTC
TTCCTCCTCCTCCACCTCCTCCTTCAACACAGTCACCTAAGTATAATCCT
AATGCGCTCCCTCAGAGGGCAATCTCTCCCGAAACTACCTTCCAGCCACC
TCCAAGAGCACAAACCCAATCACCTGGCATGGCTTCTAAGACAACCCAAA
GGCCAAGAGATCCATATGAACGACCTAGCTCTGCCTTCGCTCATAGTAGC
TCTTTGTCCTATGGCTCCGTAGATTTCCACCGACGTCAACAATCTCTAGG
GCATAATTTTATGGCGCCAAATGACGAGACTTTTCAAGATGTCTTGCAGA
GGTGGCATGGTGCACCGGTGTTTTGTTGGGGGTTTGGTGGGAGT

Sequences in the Contig:

SY0AAC33YL12FM1 SY0AAD3YP01FM1