Tuber melanosporum DB

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Contig Name: Contig4467
Length(NT) : 958
Best Gene Model Blast : Link to GSTUMT00008180001 E-value : 0.0
Numbers of ESTs : 2

Blast Results:

Nr Definition: conserved hypothetical protein
Accession: ref|XP_001213189.1| Score: 178 E_value: 3e-11
KEGG Definition: hypothetical protein
Accession: ani:AN1985.2 Score: 181 E_value: 6e-12
KOG Definition:
Classification: [Signal transduction mechanisms, Cytoskeleton].
Kog Number: KOG3671 Score: 112 E_value: 3e-06
PFAM Definition: Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity..
Pfam Number: pfam03154 Score: 122 E_value: 2e-07
Swissprot: P0C0V6|Y1985_EMENI

Sequence:
>Contig4467
TTGGGCGCGGCGTACCTCTCCACAAGCCCAGCCATATCCGCCCCCGCAGC
GCCATACCGCTCCAACTCCCCCTCAGCAACCCTCTTTCTAGCCACAAGCC
GCAGATTCGTATCCGTCAAGTGCACCCTATAATTCTCTAGCGCGCCAACA
GCCTCCTCATCATACACCTCACCCAGTGCATCAAACCGCACAACCCCAAC
CTTCCCACGCATGCTCTCGGCAAGCAAGGACAAATACATCGCCTTCGCCA
ACGTCCCCTTCTGCAGGGCTCCGCACGCGCCCCCGTCAGAAGCGGAATGC
GAGAGGGCACGCAACGAGAAGGCGGCGTAACCATCCGCAACCTCGAGGAT
TAGCCTGCCCAGTCGGCCCCGCTGCGCGACGAGCGATTGGTGATTGGCAA
ATATCTGGGTACGTAGACGGGCGGCGTTGGCCGGGAGGTGGTCTATCGCC
ATGGCTACCCCCCCACCCCCTGTTCCCACTTCTACATCTAGGTCGGGCTG
GACAAGTGAGATTAGGTCTTTAGCGGACCGATCTAGGAATAGAGAAATAT
CGTGCGCGATGGGTTGGATGTTATCATGGAAAACGGATAGCGCTTCGGAC
ATGCTTGCGCTTGCGCTTTTGGTGTTGGTGCTTGCGGAGGAGGAGGAGGT
GAGGAGGTCGAGGACCTCTGAAAGGTCTTCTGGTAGTTGTCGGGTGCGAA
GGGTAGTGTGCTTTAAGGAGTTTTGGAGCAGGTGTTGTTTTGCTAGTTCG
GCTCTGTAAGTGCGGAGGGATTGGTCAAGGGTCGAGGAGGTGGGGGGTTG
TGAATTGTGTGAAGGTAGTGGGGGCGGATGACGGGTGCTGGCGTCTGGGT
TCAGGTGGTTGGTTGTTAGGTCTGTGTAGAGTGTTGAAAAGAGGGGGTTT
GCCGAGAGGGTTTCGGGGGAGATTGGGGGGAGCATTGTTGTGATTGTCGT
GTGGCCAA

Sequences in the Contig:

SY0AAA4YF13FM1 SY0AAC33YJ03FM1