Tuber melanosporum DB

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Contig Name: Contig4198
Length(NT) : 1036
Best Gene Model Blast : Link to GSTUMT00011518001 E-value : 0.0
Numbers of ESTs : 4

Blast Results:

Nr Definition: No Hit Found
KEGG Definition: No Hit Found
KOG Definition:
Classification: [Intracellular trafficking, secretion, and vesicular transport].
Kog Number: KOG1984 Score: 166 E_value: 2e-12
PFAM Definition: Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity..
Pfam Number: pfam03154 Score: 193 E_value: 1e-15

Sequence:
>Contig4198
TTGGGCAACAGCCACAGAGAATCATGACTCCTCAGCAGCAACAACACCAA
CCTCCACCCCCTCAGCCCCCCTCCCAGAGTACATATATTGAGCAGGTTCC
GGGCGGATGGCCCCAGGACCCTCCCCAGCAGCCGCCCCAGCAGCCACCCC
AACAACCTGCCCAACAACCTGCCCAACAACCTGCCCAACAGCCAGTCCAG
CAGACAGCCCAACAACCCGCGCAGCCATCTTATGAAGTTGCCCCAACACT
GCAGCCTGCCGCTCCGGCCCAATCTGAGGAAGAACCAAATCCTCTAGATT
CCCTGGAGCAATTCTACGCCGACTCCATCCACCGCTTCATTGATATGATA
CAAGCGGAGGTTGCAGCTACTTCTGATGAAGAAAAATTGAGAGTATTTAC
GGAGTTCATGGAAAAGGAATACTTCATTCGAGGGGAACGGTACCCTAACG
CTCTTGGGGATATCCCTAGCAGGCAAGGAAGTGTGTTCGGTGGTATGAAG
AACCCCGATGGCCCAGCTGGCGCCCCGACTGTTGAGAGAAGCCCTGAAAT
CTCAAACAAGAAGGCAGCTTCAGATGTGTCTGTACCCCCCTTGTCCAGCG
AGCCGCAACATCACACGCCTCAGAACCAGCCACATCCCCCTAATATCCCT
TCTCCAATTCATGAAGTTGCCTACCAAGCACCTCAGCATGAAGAACCCAA
ACATCTAGAGAGGGTTGAAACTTATCAACCTTTCCGACCGGGTGCGGCCC
CGCCGAAACCTCAACAGCAAGTTGAGGATCCACCCGTCGGGAATGATGGC
TACAAGGCATTTAATCCCGCAGTCCACAGCCCTCCCCAGCAGAAACCTAC
CTCACCAGCGCCTCCCCAGCATCAAGGCTATGTTCCATTTCGTCCCAACG
AATCAACATTGCCTCTAGCAAAGACTGTAACTCCAGGCAATGGTGCACAT
GCTCCCTATAAAGCACCAGTGGCCAAGTCGGGCTCACCGCCGGCTTCTTC
GGGGTCTGATTTTGTTGCATACGACCCAAAGAGAGC

Sequences in the Contig:

SY0AAC11YE10FM1 SY0AAC27YF03FM1 SY0AAC47YL06FM1
SY0AAC6YF12FM1