Tuber melanosporum DB

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Contig Name: Contig4193
Length(NT) : 1236
Best Gene Model Blast : Link to GSTUMT00004876001 E-value : 0.0
Numbers of ESTs : 5

Blast Results:

Nr Definition: No Hit Found
KEGG Definition: No Hit Found
KOG Definition:
Classification: [Cell wall/membrane/envelope biogenesis].
Kog Number: KOG4701 Score: 205 E_value: 7e-17
PFAM Definition: Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity..
Pfam Number: pfam03154 Score: 245 E_value: 2e-21

Sequence:
>Contig4193
TTGGCTACTCTATCCTCACCCTCTCTTTTCATACCTCCTAACACTCAACG
CTCAACACTCAATCATCAATTCCTTAAAAAACTACAACAACCCTCCCCCC
CAACGCCCCAATTTACGCGCGGAGACATGCTCGACCCTACCACGCTTTCG
TCGCTCAAGGTGACGGAGTTGAAGGCCGAGTTGAAAAAGCGCGGTCTACC
TGTTGGAGGATTGAAGCAGGTGCTTGTAGAAAGGCTAGCCGAGCAAGTTA
TTCAGGAGCGCGCGGCGGCGGAGGCAGAAGCGGCGGCACTGGCGGAGGAG
GAGAGAGCAGCGGTAGACGATGCGCAGGGAGAGGAGGTGGTGAATGGAGA
TGGAATCGCGCCGGATCCTCAACCGGAGCCCCAGCCCGAACCAATACCGG
AGGTGGTCGAGGGGGAAAAAGAGGTTGTTCCTGTTCCCCAGGCGGAACCA
GAAGCGATTGTTGTCGAGGCTACGCAAGCGGTAGTTGTTGAGGGAAATGT
TATAGAACCGGAGGTTATCCAGGAGGAGGCTCCAAAACCTGAAGCTCCAA
CTGAAGATGAACCGGCTGTGATCGAAACAGCTTCCGAACCTGCACCTGAG
CCAGCGACTGAATCTGTTGCCGCTACGGAAGTTGTGGAGGGGGTGGTTTT
TGAGGAGAAGGTTGTTGAGCCAGAGGTTGTTGAGAGAGCTTCGGGCCCTG
AAGCTGAGCCTGCGCCCGAGCCGGTGGAAGCTGATCCGGTGGAAACTGAG
CTGGCGGAAACTGAGCTGGTGAAAACTGAGCCGGTGGAAACTGGGCTGGT
GGAAACTGAACCGGCGGAAACTGGGCTAGTGGAAACTGAACCGGCGGAAA
CTGGGCTGGTGGAAACTGAACCGGCGGAAACTAAGGTTGTTGAGAGAGTT
GAAGAGGAGGAAACTGGTGAATTGGTTTTGGAGTCCGGAGCTAAATTTGA
GGATGAGGTGGTAGAAGAGGCAGCTTTAAAGGAAGTGACGACCAAGACTG
AGATTGCTTCGGATGAGACACCTGGGACTGGGCCAATTATTGAAAAGAAG
GAAGAGATTCCCGTTGCGGGGCAGCCAATTTTGGAATTTGAGCCAGAGGC
TGAAATGGAGCGAATGAAGCCGGAGGGACTTGTCATTGCTGCTGTCGAAG
AGACCACCCGTGAAATGGTTAAGGATGAGGACTCAAACATGGTCGATGCA
TCTTCACTTTCATTGTCTCCTGAAAAGACTATAGTC

Sequences in the Contig:

SY0AAA21YF06FM1 SY0AAC27YD18FM1 SY0AAC46YO20FM1
SY0AAC52YJ15FM1 SY0AAC62YH01FM1