Tuber melanosporum DB

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Contig Name: Contig1869
Length(NT) : 1173
Best Gene Model Blast : Link to GSTUMT00009265001 E-value : 0.0
Numbers of ESTs : 4

Blast Results:

Nr Definition: No Hit Found
KEGG Definition: No Hit Found
KOG Definition:
Classification: [Function unknown].
Kog Number: KOG4672 Score: 124 E_value: 2e-07
PFAM Definition: Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity..
Pfam Number: pfam03154 Score: 120 E_value: 4e-07

Sequence:
>Contig1869
TTGGGGGTTTCACCAGCGATCTGCCCGGTAGGAATGTAGTCGCAACAAGA
GCTTCCCAGACAGAAGTAGAACCTGGAGGAGAGGCGGGGGGCGGTGGAGG
TGATTATTTTGCCACTCTGTTGCAGTTTCCAGACGAGGAATGGCGCAACT
TGCAGGTTATTGGGAAGGAGATTTCCAAGGGTATCGACATGGGGAAGCTG
AGGAAAGGATTGTCCATGGGGAGAGGAGATATCCCGGGGGTGCGTTGAGT
TCAAAATTGCTATAATGGCATGAAATTCCAAGGGGAAAGGGAAAAGGTTA
CTGATGCTCTGGTACAGTTTGATTCTTCCATCCTCGGACTCGATGAGGAA
TCTCGGGGGAGAAAAACTCCGCATGTGGGCTCCACAACTCCTGCCGTTGG
CGCTGCTGTAGGCACTCCTGGGCATGCCAATGGTTCGACACCTGGGGGAC
CATCCCCTGCCGGTGATGACGGTCGACCCAAGCGCGGGAAGCGAAGACGG
AACGACGGCGGGGACGATGATAATGGTATTAACGGCAGCATTGGAGGTGT
GGCAGGTGGTGGAGGTGGAGGAAACCATGGTCAGGGGCCTGGAGTAGGGC
CTGGAGCGATTGTTGAGGGCACAGCATGGGATGGGGAAAAGCGGAAAAAG
AAGCGGAAGAAGAATTCAGACATGAATTCATCTGGGCCTGCAGCAGCCGG
GAACATGATTCCCCGCCACGTACAAGGAGGGATAGCGGTGCACGGCGGGT
ACGGCCGGTGACCACTTACCGGTGCTGTTATGTGCCGAGCGTTATGAGTT
GACGCCCAGCATAACGACGACGACGGGGGTTATTATATATATACGTATAT
ACGTTCAGTACCGAGTCACCGCCCCTTTTTACATATCTACCTGCTCACCT
TGCTACCTACTACCTACCTACCTACCCACCTATTGTCCCGGCGGATCATT
ATAGTTGATTCGTGCGCATACATGTATCCACTGGTCGGACCGGATTGGAT
TGGACCGGATTTCTTTTTCTTTTTTGTCACTGTATTTTCTTCGCCCTAGA
TTGGGTTCACTTTTTATATATCTCCCCCTCCCTCCTTAGGTGGGCAAAGA
GGGGAAGGGGATCGGTTATTAGTGCCTACCTGTCTACGTACCCATGTCAC
ATTTACTTGCTAACTGGCTTTCC

Sequences in the Contig:

SY0AAA31YM14RM1 SY0AAA33YO14FM1 SY0AAA7YB10FM1
SY0AAB59YD02FM1