Tuber melanosporum DB

You are here: MycorWeb Genome resources Tuber melanosporum DB EST & Gene Sequences -> Contig card

Contig Name: Contig1861
Length(NT) : 945
Best Gene Model Blast : Link to GSTUMT00001155001 E-value : 0.0
Numbers of ESTs : 4

Blast Results:

Nr Definition: No Hit Found
KEGG Definition: No Hit Found
KOG Definition:
Classification: [Function unknown].
Kog Number: KOG2678 Score: 129 E_value: 3e-08
PFAM Definition: Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity..
Pfam Number: pfam03154 Score: 110 E_value: 4e-06

Sequence:
>Contig1861
TTGGCAGCACCCAACTCTCCCTCCATCCCTCCTTCCCCCCACCCCACCAA
ACAAACGGACAAACATCACTATGGCCCTCCCTATCGCCGCCACAGAATCG
ACAATAACCACAAAAAACTTGACCCGCCTCCTCTCCCGCCTCGACTCAAA
ACTCGCATCCCGAAAAGCCGCGCCCCTCTCCACGGTCGACCGCGCAAAGT
TCGCCGCGAACCTTGAGTACGCCCGACAACTCCTCCTCTCGCTGGAAAGC
GAACCATCACTCATTCGGAATGCGTCCACGCGGCAGAGCGTGCTTTCTGG
ACTGGGCGTCCAGAAGCAAGCTATTCGAAGGCTGAACGAGCAGTTGCTTG
TTATGGCTGCTGAGGGGGAGGAGGAAGGAGGGGGCTCTACTGATGACGAC
AGCGATGGGGAGGAGGAAGAAGAGGTAAAAGAGGTATCCGCGCTCCCAGC
GCAAGTAAACGGCGGAGAACGCCCACAGCAGTCGGAAAGCATCCCTGCGC
CCGCAACAACCACAACCTCTACCCTCCGAAATCGCTTCCAACAACCAACC
ACCACCCCCACCAACCATCACCAGCGCGAGCAACTCTTCCCTCCCCGCCC
CGACCCAACCGCAGCAGCCACCGACACCAACACCGACACCGAGAAGCACC
TCGACCACCAACGCGCCGAGCAGGAGCACATAACCGCAGATATGCTCTCG
CTCGCTCAGGCGCTCAAGCAGTCCTCCCTGCGCTTCGGCAGCGAGTTGGA
GAACGAGAAGGTGTTGCTGGACATGGCGCGGGAAGGGCTCGACAAGAATG
CCTTGGGGATCGAAGGCACCGGGATGAAGTTGAAGGCGCTAAGGCAGGAT
GAGAGTGTGGGGTTTTTGTGGTCGATTCTGTATCCTGTCATTATTGTCGG
GTTGGCTTTCATGGTGCTCTTTGTACTATTTTTTGCGCCCAAGTT

Sequences in the Contig:

SY0AAA6YO08FM1 SY0AAD18YB22FM1 SY0AAD35YF17FM1
SY0AAD42YL12FM1