Tuber melanosporum DB

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Contig Name: Contig1681
Length(NT) : 973
Best Gene Model Blast : Link to GSTUMT00003205001 E-value : 0.0
Numbers of ESTs : 4

Blast Results:

Nr Definition: C2H2 type zinc finger domain protein
Accession: ref|XP_001269468.1| Score: 171 E_value: 2e-10
KEGG Definition: Zn-finger
Accession: aor:AO090001000491 Score: 166 E_value: 3e-10
KOG Definition:
Classification: [Intracellular trafficking, secretion, and vesicular transport].
Kog Number: KOG1984 Score: 127 E_value: 6e-08
PFAM Definition: Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity..
Pfam Number: pfam03154 Score: 117 E_value: 7e-07

Sequence:
>Contig1681
TTGGGATCAAGACTACACCGGTTTTCAAAGATATCCTGGATACGGCCTAG
ATCAACAGCGACTAGAGGATATTAGACGAAGCACCTCACCCCATCTCCAG
GCCTCTACCCTTCCACCGTCCCAGCACCCCAGTAGCGGTCGCCAGGACTA
TTCCGACTTTTCGCTATACCCCAGCTCAACTGATCCAGCCCTCTTCGATT
ACGAAAATAAAGAGGGTTTAACCAGTGGAAGTATTAATCCTGCGGATTTG
ATTAGCTCGGCGCACTCCGCGCATTCTTCGCAGCACAACACACCGCCGTT
ACATATTCATCCTAATCAGCAACAATCATCCCAGCCCGACTCGGCTACTT
TCCTCTCTCTAGGGCCAACTAACCCCTCCCCCGGCTCCGAGTGGGATCCA
GTATTTGCACATCAGGAGAGCACTTGGAACAGCCATCGCAAGACACCTAG
TGAATACTCGGAAATCTCATCAGCTGCTGCCAGTCCATTCCTTCAGAACT
CAGAATTCCCCGAACACTCTTCGCCCCTACTTCAAGGAAGCAATCACCCC
CAGCAGGGGTCTATGCAAGATTTCTTGAACTCTAACCAAGACTTCAATCC
TGGTGGAGATTCCTTCGGGTTGGATCAATTCAGCCTCAACGAGCGCGACG
TATCACCTCACGTATCGCCTCGGGTTAGTCCGGTTCCTGGTCAATTGAAT
AGCGGTTCCAATAGTCCTTACATGTTGCCTCAGGAGAATCAGTACCTTTC
CTACGTTCCTCCCATGTCACAGGATCAAGGCATGGGACTTATGCAGCCAC
AACACCCTCCCGCCGGACATGGCCTGGGAGTTGACAGCGCTGGTCCGGGT
GAAGAGGGACCTTTCCCTCAGATCAACGTTATATTTGCTCCACCACAAAG
GCAACCCACATTCCCCGGTAAACCAGGATTTACTCATGACGACAGTGCTC
TTAGCCCCCCTCCAAAAAGTCCT

Sequences in the Contig:

SY0AAA58YK11FM1 SY0AAC41YK19FM1 SY0AAC62YH03FM1
SY0AAD36YM14FM1