Tuber melanosporum DB

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Contig Name: Contig1354
Length(NT) : 854
Best Gene Model Blast : Link to GSTUMT00007174001 E-value : 0.0
Numbers of ESTs : 2

Blast Results:

Nr Definition: hypothetical protein SS1G_06679
Accession: ref|XP_001592438.1| Score: 148 E_value: 6e-08
KEGG Definition: hypothetical protein
Accession: yli:YALI0D26191g Score: 138 E_value: 4e-07
KOG Definition:
Classification: [Cytoskeleton].
Kog Number: KOG4462 Score: 300 E_value: 4e-28
PFAM Definition: Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity..
Pfam Number: pfam03154 Score: 242 E_value: 2e-21

Sequence:
>Contig1354
TTGGGTTTGCGGGTGGGATGCCGAGGCTGAAGAGTCGGTCGGGAGGCGTT
GATACCGGAGCGTCACGGGATTCTTCATACATTTCAGATTCAGAGAGTAC
GCCTCCAAGGTCTGCGCCCATTCCTCCACGAATGCCACCGATGCCACCTA
GAGTGGGTTTACGACCGACGCCTGCTGCGCCAACCGGATCCGCACCAATA
ATTCCTTCCCAGGCGTCCCTCCGCAGACCTCCGCCCGCACCGATCAAGCG
CCCGGTCTCTTCCATTCCCATCCGCGGGGCTCCCGGCTCCCCCAGCAGCC
CGCCTTCAAGGGCCACACCTCCACCCCCGCCTCCATCATCACTAGTACCC
TCCCGCCCACTCCCATTACGCAAAACCCCATCACCTACCTCACACACCCA
AACCGATTCGCCACCCCCCAGCGCCCCTCCACCTCCACCAATCCCAGGCT
CAGCACCTAGAGTCCTTCCCCCTGGCCCACCGCGTAGTAATCCACCCCCG
CCACCTCTCCTCCCCGTCAACGGAAGCCCAAACCCAGCGTTAGCCGCCGC
ACGAAAGGTCTCCGCGACGCTCGGTGCCCACCCACCTGCCCCTCCACCAC
CCCCCCCGTCGGCAGCGCGACAATCACAGCCACTTCCACAACAGCGAGAT
TTTATGGACTCGAGCAAGTTCACCCTTACCAAGAAGAAGATGGAAATCAA
TGACTCGAGATGGAAGTTTAAGCGCGAGGAGGACTTGCCAGAACCGAGGC
CTTTTACGGGAGTTAGGAAGGTGTATCGGAGTGGGAGGGGGAGCAGCGTT
CCGCTAGATTTTGAGAGTTTGGAGTAGAGAACTGTTTTTTTTTTTTGGGG
GGGG

Sequences in the Contig:

SY0AAA48YG08FM1 SY0AAC22YD11FM1