Tuber melanosporum DB

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Contig Name: Contig1082
Length(NT) : 858
Best Gene Model Blast : Link to GSTUMT00005240001 E-value : 1e-176
Numbers of ESTs : 3

Blast Results:

Nr Definition: hypothetical protein CHGG_03206
Accession: ref|XP_001229722.1| Score: 290 E_value: 2e-24
KEGG Definition: hypothetical protein
Accession: fgr:FG05559.1 Score: 229 E_value: 1e-17
KOG Definition:
Classification: [Function unknown].
Kog Number: KOG4174 Score: 248 E_value: 4e-22
PFAM Definition: Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity..
Pfam Number: pfam03154 Score: 109 E_value: 5e-06

Sequence:
>Contig1082
TTGGCCCCAACCGCACACCCACCCAAACCAAACCACCAATACCGGTACTT
AATCAAACCCAATTCAGCCTCCTCCTTCAACTAAACCATGTCTAAAAAGC
GAAAACACACCTCTGCGCCCTCCTCTTCCTTCACCAAGCACCCGCACCCG
CACAAAATGCAAAAACTAACTCCGCAACCCCACCACCACCACCACCACCG
AAAACTCAACCACCCCAAATCCAAACACAAACCGATCGCCAAGCAACCCC
CACCACCACCGCAAAAACTCCCTACCCTCTTCCACCCCAGCTCGAGAATC
CTCCTCCTGGGCGAAGGGGATTTCTCCTTCGCTGCCTCGCTGGTGCGTCA
CCACCACGTCCGACACTTGACAGCGACGAGCTTAGATAGTGAAGCGGAGT
TATTAGAAAAGTACCCGCAGGCAGCGGGGAATATTGCCCTAGTACGGGGG
ATGGTTGGCGGTGGGGGGGTGGTGGTGCATGGTGTTGATGCCGGGGCAGT
GGAGAGAGTTAAAGCTGTGAGGAAGCGGCGTGGGGAGGTTGTGCCTGGGC
TGGTGGAGGACGGGGAGAGGGAAGAAGATGGGGAAGAGGGGAGGGAGGAG
CCGGGGGGGAGAGGGGCGGTAGGATTCGACGTAATTGCTTTCATGTTCCC
GCACATTGGCGGAAAAAGTACGCACCTGGATCGTCAGGTGCGTGATAATC
AACAACTCCTCCAATCATTCTTCGCAGCGGCGAAACCTCTCCTGTCACCT
CGTGGCGTAATTGTCGTCACATTGTTCGAAGGCAAGCATTACGAGCTCTG
GGACATCAAGGGGTTGGCAAGGGCTGTTGGATTTCAGACTCGGACGAGTT
TCAAGTTT

Sequences in the Contig:

SY0AAA36YH05FM1 SY0AAA41YH10FM1 SY0AAB3YJ01FM1