L’unité IAM au Salon de l’Agriculture

Retour en images via Twitter sur 10 jours de folie pour notre unité au Salon International de l’Agriculture à Paris…

 

Post-doc position

Using Ascobolus immersus as a genetic model for understanding the sexual reproduction of the truffle.

Job description: The successful applicant will work for a joint project between INRA-Nancy-Lorraine, University Paris Sud and CNR-IBBR Perugia.

The aims of the project AscoTube are to 1) use Ascobolus immersus as a genetic model species to assess the truffle strains recognition in vitro and 2) better understand the truffle sexual reproduction in situ.

The successful applicant is expected:

1) to set cassettes and transform A. immersus with mating type genes from both Tuber melanosporum and Tuber indicum, previously identified by means of genomic and genetic tools;

2) to test the intra and inter specific recognition of these genes;

3) to follow the dynamics of strains of different mating type in the soils of truffle a plantation, in the root system and in the fructification.

Requirements

PhD in Microbiology or Molecular biology or related science.

Experience in molecular genetics, molecular biology as well as knowledge on fungal genetic transformation, soil DNA extraction and quantitative PCR will be an advantage.

Communicate in English with other members of the lab as well as other members of the project.

Working language(s): English, French and Italian

Application

Applicants should submit (1) a cover letter describing their research interests and background, (2) a detailed CV , and (3) the contact details of three referees.

Contact

Claude Murat, INRA Centre Nancy-Lorraine, UMR1136, 54280 Champenoux, France, claude.murat@nancy.inra.fr

Fabienne Malagnac, University Paris-Sud, UMR 9198, 91400 Orsay cedex, France, fabienne.malagnac@u-psud.fr

Francesco Paolocci, CNR Perugia, IBBR, Via Madonna Alta, 130, 06128 Perugia, Italy, francesco.paolocci@ibbr.cnr.it

Research Teams’ Publications

http://mycor.nancy.inra.fr/IAM/?page_id=318

http://www.i2bc.paris-saclay.fr/spip.php?article69

http://ibbr.cnr.it/ibbr/publications/

Employer: INRA Nancy-Lorraine

Department & Research Team: Tree-microbe-interactions UMR1136

Place of work: Nancy /France, Orsay/France (for short period) and Perugia/Italy (for 3-6 months)

Duration: 12 months starting September 2016

Salary & Working hours: INRA Post-Doc depending on experience, 38.5h/week

Application deadline: July 15th, 2016

 

 

 

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Post-doc position

Towards new eco-friendly strategies to limit fungal attacks on plants and wood

Project: The adaptive capacity of a target population of fungi is intimately correlated with the selective pressure exerted by its local niche. This is due to the chemical specificity of these niches, which could be rich in secondary metabolites in the case of plants or rich in lignin-derived compounds in the case of wood. We have shown that lignolytic fungi have expanded detoxification systems composed by cytochrome P450 monooxygenases (P450s) and conjugating enzymes, allowing them to detoxify a large panel of toxic compounds that could be released during the wood degradation process. These enzymes are known to be highly versatile (i.e. they accept various substrates), with high catalytic promiscuity (i.e. only small sequence variations could modify their catalytic properties and the type of reactions catalyzed). Hence, by rapidly acquiring new functions under environmental pressures (neofunctionalization), these enzymes are part of the mechanisms developed by fungi to adapt to their changing environment. Thus, thanks to their efficient detoxification and antioxidant systems, fungi are amazing organisms able to resist hostile environments.

This project aims both at evaluating the antifungal capacity of various environmental extracts from plants and wood, and at delineating the underlying molecular mechanisms explaining the growth phenotypes of various fungal strains observed in presence of the tested extracts. By coupling these two approaches, we expect identifying natural extracts with antifungal activity and deciphering how they affect fungal metabolism. The expected results could help better understanding fungal physiology, evolutionary history and adaptation, knowledge that are required for developing new eco-friendly strategies to limit fungal attacks on crops and on wood material.

Required skills: This project combines genomic, transcriptomic, physiological, biochemical and chemical approaches. The candidate needs to have a strong expertise in molecular biology, fungal microbiology and bioinformatics. For this project, he will benefit from the expertise of many scientists in the research unit (see website: http://mycor.nancy.inra.fr/IAM/) with a strong background in these disciplines and from external existing collaborations for sample extraction and chemical analyses, fungal genetic transformation, or for protein structural analysis.

Place of work: Stress Responses and Redox Regulation” team (http://mycor.nancy.inra.fr/IAM/?page_id=17). Faculty of sciences, Vandoeuvre-lès-Nancy, France

Form of employment: Temporary employment for one year funded by the Région Lorraine and Lorraine University, possibly renewable and starting in autumn 2016.

Applicants should sent a CV, including the names and contact details of three referees, and a covering letter addressing the selection criteria to Dr Mélanie Morel-Rouhier, e-mail: Melanie.Morel@univ-lorraine.fr, phone: +33 3 83 68 42 28.

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Postdoctoral Position in Comparative Genomics and Symbiosis Evolution

Institution: INRA, UMR IAM, Lab of Excellence ARBRE

Location: Nancy, France

Job Description: 

A postdoctoral researcher position is available immediately in the lab of Francis Martin at the Tree-Microbe Interactions Department at INRA in Nancy, France. Martin’s lab uses computational approaches to study how saprotrophic and symbiotic (mycorrhizal) fungi evolve and adapt to their environments. Ongoing projects fall into the following broad areas: 1) Studying the emergence of the symbiotic mutualism in fungal and tree species by phylogenomics; 2) Characterization of symbiosis-related genes by using comparative transcriptomics; and 3) Deciphering genomic signatures of fungal adaptations to carbon decay and sequestration in forest habitats by metatranscriptomics. More information about Martin’s lab.

Qualified applicant must have a Ph.D. in bioinformatics, computational biology, computer science, evolutionary biology or a related field with background and strong interest in molecular evolution of Fungi. The ideal candidate will already have some experience working with large genomic data sets from sequenced fungi or plants. This position requires a high level of proficiency in programming skills, and experience applying computational methods to genomic data is highly desirable. Applicants must possess good communication skills and be fluent in both spoken and written English (or French). Strong skills in the use of unix-based computer softwares, critical thinking, problem-solving abilities, and the ability to work semi-independently are also required. The responsibilities will include pipeline development for analyses of next-generation data sets and utilization of high-performance computing facilities.

The successful candidate should anticipate contributing to a variety of ongoing collaborative research projects with the Joint Genome Institute, including the 1000 Fungal Genomes project and the Mycorrhizal Genomics Initiative, with teams across France, Europe and the United States. In addition to becoming a part of a vibrant research and educational environment, the incumbent can take advantage of professional development programs offered by Laboratory of Excellence ARBRE.

The initial appointment is for one year with the possibility of renewal for up to two additional years contingent upon performance and funding. Review of applications will begin immediately and continue until the position is filled. Start date is July 1st, 2016 at the latest.

Interested applicants should send a single PDF file containing CV, one-page statement of research interests and contact information of three referees to Francis Martin at fmartin[at]nancy.inra.fr.

 

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Thomas Perrot, finaliste au concours MT180 sec !

Bandeau MT180

Venez nombreux pour soutenir Thomas, à la finale régionale du concours « Ma thèse en 180 secondes », qui aura lieu jeudi 28 avril, de 18h30 à 20h30, dans l’amphithéâtre Déléage (A027) du campus Lettres et Sciences Humaines de Nancy (23 boulevard Albert 1er). Entrée libre et gratuite !

Retrouvez l’interview de Thomas ici et plus d’infos ici.

Thomas Perrot MT180 b

CCD Ingénieur en Informatique

Nous sommes à la recherche d’un Ingénieur en Informatique pour un CDD de 1 an renouvelable 6 mois.
Le poste sera hébergé au sein d’une équipe de biologie évolutive et d’écologie à l’INRA de Nancy (UMR 1136 Interactions Arbres-Microorganismes).
La personne aura pour mission principale de contribuer au développement du logiciel EggLib (bibliothèque contenant des outils d’analyse pour la génétique des populations, http://egglib.sourceforge.net/) dans le cadre du projet ANR Gandalf. Les missions sont plus particulièrement : (1) d’améliorer la stabilité de la bibliothèque, (2) de la rendre plus facile d’accès pour les utilisateurs et (3) de faciliter les tâches de développement futures. Pour plus d’information, voir le profil détaillé joint à cette annonce.Formation requise :
Master (ou plus) en Informatique, idéalement avec option Ingénierie Logicielle. Le/la candidat(e) devra avoir l’expérience du développement et de la distribution de modules sous python, ainsi qu’une connaissance au moins théorique des méthodes et outils du développement logiciel. Un bon niveau de compréhension et de rédaction en anglais scientifique serait apprécié.Prise de fonction : mi-mars. Les candidatures seront examinées au fur et à mesure jusqu’à ce que le poste soit pourvu.Pour candidater, envoyer votre CV (incluant les noms et contact de 1 à 2 personnes référentes) et votre lettre de motivation à :
Stéphane De Mita : sdemita@nancy.inra.fr
ou
Fabien Halkett : halkett@nancy.inra.fr

Plus d’informations ici : profil CDD Gandalf
.
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Seminar: Martin Lascoux

MartinLascoux2

Pr. Martin Lascoux, Professor at the Department of Ecology and Genetics, Uppsala University (Sweden) will be at INRA-Nancy on Dec 15th for the PhD dissertation of Antoine Persoons. He will give a seminar in the conference room of INRA Nancy at 10:00 am on the following topic:

“Clinal variation and the genetic basis of adaptive traits in trees”

Here is an abstract of his seminar:

Identifying the loci underlying the variation in quantitative traits and detecting the selection acting on them remains, to this day, one of the main challenges in biology. Genome wide association studies (GWAS) have become the main approach to identify the genetic factors controlling complex traits. Limitations of GWAS have, however, started to become evident and different strategies have been offered to alleviate those. In particular, GWAS have limited power unless very large datasets are used. They therefore remain prohibitively expensive, and often not so informative, for non-model organisms with limited or nascent genome resources such as forest trees. So, at least in the short term, a more targeted strategy, combining common gardens, population genetics, physiological and expression studies of candidate genes remains a very fruitful alternative. We will illustrate this with recent studies of clinal variation in phenological traits in forest trees, with special focus on boreal conifers, oaks and poplars. Some general features emerge from these different studies: first, they confirm the presence of strong latitudinal clines in phenological traits such as growth cessation. Second, most of the studies highlight the importance of genes belonging to the photoperiodic pathway and the circadian clock in the control of growth cessation. For instance, in both Norway and Siberian spruces, FTL2, a homolog of the main integrators for flowering time in A. thaliana, exhibits evidence of local adaptation and significant latitudinal variation in expression. Finally, the study of parallel clines in phenological traits, offers a first glimpse at the importance of parallel or convergent evolution in forest trees. They thereby provide us with a bit of information on the genetic architecture of important adaptive traits.

Please join us for this seminar.

PhD position

English version: see below

Titre du sujet de thèse :

Architecture génétique de traits d’histoire de vie liés au pouvoir pathogène de l’agent de la rouille du peuplier.

Encadrants :

Pascal FREY (DR2, HDR), directeur de la thèse

Fabien HALKETT (CR1), co-encadrant

Stéphane DE MITA (CR2), co-encadrant

Laboratoire d’accueil :

UMR Interactions Arbres – Microorganismes

INRA/Université de Lorraine

Centre INRA Nancy-Lorraine

54280 Champenoux

http://mycor.nancy.inra.fr/IAM/

Université d’inscription de l’étudiant en thèse : Université de Lorraine

Ecole doctorale : RP2E (Ressources, Procédés, Produits, Environnement)

Financement (acquis) : INRA Département EFPA (Ecologie des Forêts, Prairies et milieux Aquatiques) & Région Lorraine

Résumé de la thèse

L’objectif de la thèse est d’étudier l’architecture génétique de traits d’histoire de vie liés au pouvoir pathogène de l’agent de la rouille du peuplier, Melampsora larici-populina. Nous faisons l’hypothèse que l’agressivité du champignon risque d’augmenter suite au déploiement au champ de nouveaux cultivars de peuplier portant des résistances quantitatives. L’objectif général de cette thèse est de mieux comprendre le potentiel d’évolution de l’agressivité des agents pathogènes, afin d’alimenter la réflexion sur les stratégies de sélection de résistances durables, en particulier chez le peuplier.

Contexte et enjeux

Le peuplier constitue une production importante en Europe pour le bois d’industrie et sa contribution à des filières énergétiques est en nette progression. La rouille du peuplier, causée par le champignon pathogène Melampsora larici-populina constitue la principale contrainte phytosanitaire de la populiculture en Europe et dans le monde. La sélection de variétés de peupliers résistants à la rouille était basée pendant des décennies sur la sélection d’hybrides F1 interspécifiques, portant majoritairement des résistances qualitatives monogéniques et dominantes, basées sur la relation gène-pour-gène. Cependant, les déploiements successifs au champ de cultivars de peuplier à résistances qualitatives se sont soldés par les contournements systématiques de ces résistances par l’agent pathogène, témoignant de leur caractère non durable à moyen et long terme (Xhaard et al., 2011). La connaissance du déterminisme génétique des facteurs de virulence qui causent les contournements de résistance serait souhaitable, tant sur le plan fondamental (interactions entre loci d’avirulence et loci de résistance) que sur le plan appliqué (stratégies de gestion spatio-temporelle des résistances qualitatives).

Depuis une vingtaine d’années, la recherche de résistances plus durables a conduit les améliorateurs à s’orienter vers la sélection de résistances quantitatives, à déterminisme génétique plus complexe. Cependant, la résistance quantitative peut également s’éroder du fait de l’augmentation de l’agressivité des agents pathogènes, définie comme la composante quantitative du pouvoir pathogène (Pariaud et al., 2009). Par conséquent, il est primordial d’étudier l’évolution potentielle des traits d’agressivité et leurs éventuels compromis évolutifs (Lannou, 2012).

De plus, la sélection de traits favorables peut conduire à des trade-offs, c’est-à-dire des compromis entre traits d’histoire de vie (Laine & Barrès, 2013). Les trade-offs entre traits peuvent refléter des stratégies d’adaptation de l’agent pathogène à l’hôte (compétition et/ou dispersion) suivant les traits sur lesquels les individus investissent prioritairement (Pariaud et al., 2009) et peuvent donc jouer un rôle primordial au cours des processus épidémiques. L’étude de ces trade-offs entre traits quantitatifs peut ainsi permettre de mieux comprendre les paramètres qui conditionnent une épidémie.

Hypothèses de travail et objectifs de la thèse

L’hypothèse principale est que l’agressivité de M. larici-populina pourrait augmenter suite au déploiement de nouveaux cultivars de peuplier portant des résistances quantitatives. Par conséquent, une connaissance de l’architecture de ces traits et de leurs trade-offs éventuels devrait permettre d’orienter les stratégies de sélection pour des résistances durables (McDonald & Linde, 2002).

L’objectif central de la thèse proposée est d’étudier l’architecture génétique des traits d’histoire de vie qualitatifs (facteurs de virulence) et quantitatifs (composantes d’agressivité) chez l’agent de la rouille du peuplier. Pour cela, les techniques de NGS (Next Generation Sequencing) seront utilisées.

Les objectifs détaillés de ce projet de thèse seront :

  1. de cartographier les facteurs de virulence et les QTL d’agressivité par une approche de re-séquençage de descendances (autofécondations et allofécondations) obtenues par croisements contrôlés de M. larici-populina (Pernaci et al., 2014 ; Pernaci 2015).
  2. de cartographier ces mêmes traits qualitatifs et quantitatifs par une approche de GWAS (Genome-Wide Association Study ; Hamblin et al., 2011) sur des populations naturelles de M. larici-populina.
  3. d’étudier les compromis évolutifs (trade-offs) entre ces traits, qui peuvent conditionner l’adaptation de M. larici-populina aux résistances du peuplier.

Publications récentes des responsables de la thèse, en rapport avec le projet proposé :

Pernaci, M., De Mita, S., Andrieux, A., Pétrowski, J., Halkett, F., Duplessis, S., and Frey, P. (2014). Genome-wide patterns of segregation and linkage disequilibrium: the construction of a linkage genetic map of the poplar rust fungus Melampsora larici-populina. Frontiers in Plant Science 5, 454.

Persoons, A., Morin, E., Delaruelle, C., Payen, T., Halkett, F., Frey, P., De Mita, S., and Duplessis, S. (2014). Patterns of genomic variation in the poplar rust fungus Melampsora larici-populina identify pathogenesis-related factors. Frontiers in Plant Science 5, 450.

Barrès, B., Dutech, C., Andrieux, A., Halkett, F., and Frey, P. (2012). Exploring the role of asexual multiplication in poplar rust epidemics: impact on diversity and genetic structure. Molecular Ecology 21, 4996-5008.

Xhaard, C., Barrès, B., Andrieux, A., Bousset, L., Halkett, F., and Frey, P. (2012). Disentangling the genetic origins of a plant pathogen during disease spread using an original molecular epidemiology approach. Molecular Ecology 21, 2383-2398.

Xhaard, C., Fabre, B., Andrieux, A., Gladieux, P., Barrès, B., Frey, P., and Halkett, F. (2011). The genetic structure of the plant pathogenic fungus Melampsora larici-populina on its wild host is extensively impacted by host domestication. Molecular Ecology 20, 2739-2755.

Autres références bibliographiques

Hamblin, M.T., Buckler, E.S., and Jannink, J.L. (2011). Population genetics of genomics-based crop improvement methods. Trends Genet 27, 98-106.

Laine, A.L., and Barrès, B. (2013). Epidemiological and evolutionary consequences of life-history trade-offs in pathogens. Plant Pathology 62, 96-105.

Lannou, C. (2012). Variation and selection of quantitative traits in plant pathogens. Annual Review of Phytopathology 50, 319-338.

McDonald, B.A., and Linde, C. (2002). Pathogen population genetics, evolutionary potential, and durable resistance. Annual Review of Phytopathology 40, 349-379.

Pariaud, B., Ravigné, V., Halkett, F., Goyeau, H., Carlier, J., and Lannou, C. (2009). Aggressiveness and its role in the adaptation of plant pathogens. Plant Pathology 58, 409-424.

Pernaci, M. (2015). Etude des traits d’histoire de vie de Melampsora larici-populina, agent de la rouille du peuplier : de leur déterminisme génétique à leurs conséquences évolutives. Thèse de Doctorat, Université de Lorraine, 200 p.

Candidature :

Envoyer un CV, une lettre de motivation et les coordonnées de 2 personnes de référence à Pascal Frey (pascal.frey@nancy.inra.fr) avant le 1er octobre 2015.

Compétences recherchées

Le(la) candidat(e) devra avoir de bonnes compétences en génétique (génétique quantitative, génétique des populations, génomique) et en bioinformatique. Il(elle) devra avoir des connaissances de base en écologie et un intérêt pour la biologie évolutive et la pathologie végétale. Un goût prononcé pour le travail en équipe est indispensable.

 

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Title of the thesis

Genetic architecture of pathogenicity-associated life history traits in the poplar rust fungus.

Advisors:

Pascal FREY (Senior scientist), main supervisor

Fabien Halkett (Junior scientist), co-supervisor

Stéphane DE MITA (Junior scientist), co-supervisor

Host laboratory

Department of Tree – Microbe Interactions

INRA / University of Lorraine

INRA Nancy-Lorraine Research Centre

54280 Champenoux

http://mycor.nancy.inra.fr/IAM/

 Funding (acquired): INRA EFPA Scientific division (Ecology of Forests, Grasslands and Aquatic environments) & Region Lorraine. Duration 3 years. Monthly net salary about €1400.

 Thesis summary

The aim of the thesis is to study the genetic architecture of life history traits related to pathogenicity in the poplar rust fungus, Melampsora larici-populina. We assume that the aggressiveness of the fungus may increase following the deployment in the field of new poplar cultivars with quantitative resistance. The general objective of this thesis is to better understand the potential evolution of aggressiveness in pathogens, to fuel the debate on sustainable resistance breeding strategies, especially in poplar.

Context and challenges

Poplar is an important product for the wood industry worldwide and its contribution to energy systems has increased recently. Poplar rust, caused by the pathogenic fungus Melampsora larici-populina, is the main phytosanitary constraint for commercial poplar cultivation in Europe and worldwide. In the last 50 years many rust-resistant cultivars were bred and released, but each of the qualitative resistance genes (i.e. major resistance genes) released have been overcome by pathogen evolution within a short period (Xhaard et al., 2011). Qualitative resistance is particularly subject to breakdown by pathogen evolution for perennial hosts, such as poplar trees, because of the wide inequality between the pathogen’s rapid generation time and the time needed to deploy new host varieties. Knowledge of the genetic determinism of the virulence factors leading to resistance breakdown would be beneficial both from an academic perspective (e.g. to decipher interactions between avirulence loci and resistance loci) and from an applied perspective (e.g., for determining strategies of spatiotemporal management of qualitative resistance).

The failure of qualitative resistances to control poplar rust has prompted breeders to search for quantitative resistance, which is supposed to be more durable. However quantitative resistance can also be challenged by the evolution of aggressiveness, which is the quantitative component of pathogenicity, determined by several disease-associated traits (Pariaud et al., 2009). Thus it is of primary importance to assess the potential evolution of aggressiveness traits in the pathogen and the potential trade-offs between these traits (Lannou, 2012; Laine & Barrès, 2013).

Working hypotheses and objectives of the thesis

The main hypothesis is that the aggressiveness of M. larici-populina could increase following the deployment of new poplar cultivars with quantitative resistance. Therefore, knowledge of the architecture of aggressiveness traits and their potential trade-offs would be useful in order to guide breeding strategies towards durable resistance (McDonald & Linde, 2002).

The central aim of the proposed thesis is to study the genetic architecture of qualitative (virulence factors) and quantitative (aggressiveness components) traits in the poplar rust fungus. To this aim, whole-genome re-sequencing techniques will be used.

The detailed objectives of this PhD project will be:

  1. To map avirulence loci and aggressiveness QTLs through whole-genome re-sequencing of selfed and/or outcrossed progenies obtained from controlled crosses of M. larici-populina (Pernaci et al, 2014; Pernaci 2015).
  2. To map the same kind of qualitative and quantitative traits through an approach of Genome-Wide Association Study (GWAS; Hamblin and al., 2011) in natural populations of M. larici-populina.
  3. To assess the potential trade-offs between those traits, which can condition the adaptation of the pathogen to the resistance of the host.

 Recent publications of the thesis advisors in relation to the proposed project

Pernaci, M., De Mita, S., Andrieux, A., Pétrowski, J., Halkett, F., Duplessis, S., and Frey, P. (2014). Genome-wide patterns of segregation and linkage disequilibrium: the construction of a linkage genetic map of the poplar rust fungus Melampsora larici-populina. Frontiers in Plant Science 5, 454.

Persoons, A., Morin, E., Delaruelle, C., Payen, T., Halkett, F., Frey, P., De Mita, S., and Duplessis, S. (2014). Patterns of genomic variation in the poplar rust fungus Melampsora larici-populina identify pathogenesis-related factors. Frontiers in Plant Science 5, 450.

Barrès, B., Dutech, C., Andrieux, A., Halkett, F., and Frey, P. (2012). Exploring the role of asexual multiplication in poplar rust epidemics: impact on diversity and genetic structure. Molecular Ecology 21, 4996-5008.

Xhaard, C., Barrès, B., Andrieux, A., Bousset, L., Halkett, F., and Frey, P. (2012). Disentangling the genetic origins of a plant pathogen during disease spread using an original molecular epidemiology approach. Molecular Ecology 21, 2383-2398.

Xhaard, C., Fabre, B., Andrieux, A., Gladieux, P., Barrès, B., Frey, P., and Halkett, F. (2011). The genetic structure of the plant pathogenic fungus Melampsora larici-populina on its wild host is extensively impacted by host domestication. Molecular Ecology 20, 2739-2755.

 Other references

Hamblin, M.T., Buckler, E.S., and Jannink, J.L. (2011). Population genetics of genomics-based crop improvement methods. Trends Genet 27, 98-106.

Laine, A.L., and Barrès, B. (2013). Epidemiological and evolutionary consequences of life-history trade-offs in pathogens. Plant Pathology 62, 96-105.

Lannou, C. (2012). Variation and selection of quantitative traits in plant pathogens. Annual Review of Phytopathology 50, 319-338.

McDonald, B.A., and Linde, C. (2002). Pathogen population genetics, evolutionary potential, and durable resistance. Annual Review of Phytopathology 40, 349-379.

Pariaud, B., Ravigné, V., Halkett, F., Goyeau, H., Carlier, J., and Lannou, C. (2009). Aggressiveness and its role in the adaptation of plant pathogens. Plant Pathology 58, 409-424.

Pernaci, M. (2015). Etude des traits d’histoire de vie de Melampsora larici-populina, agent de la rouille du peuplier : de leur déterminisme génétique à leurs conséquences évolutives. Thèse de Doctorat, Université de Lorraine, 200 p.

 Application

Send CV, cover letter and contact details of two referees to Pascal Frey (pascal.frey@nancy.inra.fr) before 1 October 2015.

 Required skills

The candidate should have good skills in genetics (quantitative genetics, population genetics, genomics) and bioinformatics. He/she should have basic knowledge in ecology and an interest in evolutionary biology and plant pathology. A taste for teamwork is essential. Knowledge of French will be an asset but is not mandatory.

 

 

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